Can AI Reason From Marker Genes? Building a Single-Cell Benchmark From PBMC3k
Most single-cell RNA-seq examples end with this pattern: load data preprocess cluster cells generate UMAP rank marker genes assign cell labels That wo…
Programming
⚑ Report a ProblemLatest Programming news from Tech News
All topics
AI
agents
ai
api
architecture
automation
aws
beginners
career
claude
database
devchallenge
devops
javascript
learning
llm
machinelearning
mcp
opensource
performance
productivity
programming
python
react
rust
security
showdev
tutorial
typescript
webdev
Your UMAP Looks Great. But Can You Prove the Annotation Is Correct?
How I built a production scanpy pipeline that does not just annotate single-cell data -- it measures how accurately it did so, where it fails, and why…
The Evolution of Circuit Compression
Miniaturization replaced the tube with the transistor. The currency of compromise changed from watts of heater power to milliwatts of leakage and diss…
Truthful AI Under Pressure: What Kradle.AI Might Reveal About Fable 5
Do you know what many neurodivergent people have deeply rooted in them? A relationship with truth and justice. In psychology, this phenomenon is often…
Do You React Faster to Sound or Sight? Test Both in Your Browser
Every article that answers this question just quotes a study and moves on. The interesting part is that you can reproduce the finding yourself in abou…
Low Pass Filter Design: Setting the Cut-off with Two Components
Plug an oscilloscope probe into almost any real circuit and the trace will be fuzzy. Riding on top of the signal you actually want is a haze of higher…
The Bolted Flange Joint: Why the Bolts Carry Far More Than the Pressure
A flanged pipe joint looks simple: two raised faces, a gasket between them, a ring of bolts pulling them together. Yet the gasketed bolted flange is o…
## The Expertise Paradox: Seeing Differently, Not Just Knowing More
The Expertise Paradox: Seeing Differently, Not Just Knowing More Research across domains reveals a consistent pattern: experienced practitioners recog…
Abortion Rights Matter
Aidan Jones Abortion 29 May 2026 Abortion Rights Matter Nevaeh Crain should have lived to see her 21st birthday. Tragically, on October 29, 2023, she …
Stress Concentration Factor: Why a Small Hole Can Triple Local Stress
A crack in an aircraft window, a fracture starting at a bolt hole, a shaft that snaps at the shoulder where the diameter steps down. These failures sh…
Future of AI Hardware
Over the few days I studied computer architecture and it really changed my view of Artificial Intelligence. I started with RISC-V International. Learn…
How AI and Electronics Are Changing Healthcare Devices: The Future of Smart Healthcare Author: Shivam Wakade | Founder, PrivSR
Introduction Healthcare has always relied on one important factor: timely and accurate information. Doctors, nurses, and healthcare professionals make…
Bearing Life (L10): What the Catalog Number Really Tells You
Open any rolling-bearing catalog and you will find, next to each part, a number called the dynamic load rating, C. It is tempting to read it as "the l…
PID Tuning That Actually Converges: Ziegler-Nichols and the Root Locus View
The PID controller is the workhorse of industrial control. It runs temperature loops, motor drives, flow valves, and flight surfaces. The algorithm it…
Differential Pair Impedance: Why USB and HDMI Routing Is a Geometry Problem
Every fast interface on a modern board — USB, HDMI, PCIe, Ethernet, SATA — sends its data as a differential pair: two traces carrying equal and opposi…
Reading a Psychrometric Chart Without Getting Lost
The psychrometric chart is one of the most information-dense diagrams in engineering. To a newcomer it looks like a tangle of curved and slanted lines…
I forked MathLive to make basic chemistry formulas less awkward
I recently published a small MathLive fork: GitHub: https://github.com/LatoAndroid/mathlive-chemistry npm: https://www.npmjs.com/package/mathlive-chem…
Hertz Contact Stress: How to Predict Pressure Where Two Surfaces Meet
When a hardened steel ball rests on a flat plate, the entire load passes through a contact patch smaller than a pinhead. Intuitively you might expect …
Google Wants AI to Run the Scientific Method
Google launched Gemini for Science yesterday at I/O 2026, and it is the most interesting thing to come out of the keynote. Not the smart glasses, not …
Two AI-based science assistants succeed with drug-retargeting tasks
Both tools generate hypotheses; one goes on to analyze some of the data.
Fiber Optic Camera – Bringing Vision to Impossible Places
Conventional machine vision places the camera at the inspection point. The lens points at the target, and the sensor sits right behind it. This works …
Understanding Importance Derivation
Hello, I'm Ganesh. I'm building git-lrc , an AI code reviewer that runs on every commit. It is free, unlimited, and source-available on GitHub. Star g…
The Science of Zen: Why Ambient Radio is the Ultimate Tool for Stress Relief
Modern life is loud. Notifications, emails, sirens, and the constant hum of a digital world keep our nervous systems on high alert. This chronic state…
Weak World Models vs Strong World Models in Biomedicine
Why early medical world models should start as auditable transition priors, not black-box drug-response engines. Most medical AI systems today are bui…
Why text-to-image AI keeps failing at scientific figures (and what actually works)
Over the past month I've been trying to replace my "spend half a day in Illustrator drafting figures" workflow with AI tools. I tried Midjourney, GPT-…
AI Needs RNA, Not Just Weights
There is a creature at the bottom of the ocean that solves intelligence differently than every other animal on Earth. The octopus has no centralized c…
THE ENGINEERING OF ELECTRICAL VERTICAL TAKEOFF: A deep technical study
Every eVTOL conceals the same brutal physical contradiction. Hovering demands enormous disc area and low disc loading to minimise induced power. Effic…
Why we built provenance into a notes app
Notes written in the field are good at recording results and reflections, but keeping the flow that led to those results as structure is surprisingly …
Study: AI models that consider user's feeling are more likely to make errors
Overtuning can cause models to "prioritize user satisfaction over truthfulness.”